Indigo is a EC Horizon 2020 project in partnership with India’s Department of Biotechnology
Project INDIGO is jointly funded research and innovation project funded by the European Commission, as part of the Horizon 2020 research and innovation program, and India’s Department of Biotechnology. INDIGO is a 5-year program aimed at moving towards a next generation influenza vaccine. This program contributes to Sustainable Development Goal 3: to ensure health and well-being, at every stage of life.
INDIGO is part of call: SC1-BHC-32-2019, Project 874653
Influenza is a major global health burden, with an estimated 500,000 deaths annually. Each year, the influenza pandemic impacts millions of people worldwide. What starts with a relatively simple flu infection, may evolve into a serious, or even fatal, secondary infection.
The goal of INDIGO is to promote the development of vaccines that can alleviate the global burden of influenza, especially through the protection of vulnerable and underserved populations
Improve the overall efficacy and impact of flu vaccines
Test a low dose of influenza vaccine antigen in combination with a novel adjuvant called LVA, with the goal to reduce the cost of goods and promote affordability especially in low- and middle-income countries
Improve the immunogenicity of the most commonly used antigen for influenza vaccine (HA protein) by modifications to this protein
Study the reasons why people decide whether or not to take their flu shot, and design strategies to help people making the right choices. We will also study cultural differences between the EU and India.
Investigate methods to improve the cellular immunity to the vaccine, e.g. by trying new adjuvants and improve the route of vaccination
Develop a needle-free application of the experimental vaccines by using microneedle patches for intradermal application
Investigate whether the combination of the modified HA protein along with a novel adjuvant (an extra compound in the vaccine to boost the immune-response) will act synergistically in the induction and development of protective immunity
Eleviate the regulatory hurdles that prohibit the distribution of vaccines especially during a pandemic crisis, both for developed and developing countries
Clinical Evaluation: Consortium members of this cluster will conduct the formal pre-clinical toxicity studies along with the phase I and phase II clinical trials.
Nonclinical Evaluation: Consortium members of this cluster will conduct the nonclinical immunology and pharmacology studies. They will also focus on the mode of action studies on the adjuvant in animals and in vitro with human immune cells
Novel Antigens and Adjuvants: Consortium members of this cluster will design the antigens, conduct feasibility studies in animals and prepare research material for the nonclinical evaluation team and cGMP batches of antigen and adjuvant for the clinical evaluation teams
Exploitation and Dissemination: Consortium members of this cluster will work to prepare the market for the next generation of flu vaccines through the regulatory framework of proprietary technologies and exploitation of the seasonal and pandemic flu vaccines. Additionally, this cluster will also focus on increasing the uptake of the vaccine in both the developing and developed countries